General Information

  • ID:  hor006133
  • Uniprot ID:  P22334
  • Protein name:  Insulin-like peptide A chain
  • Gene name:  ILP
  • Organism:  Branchiostoma californiense (California lancelet) (Amphioxus)
  • Family:  Insulin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Branchiostoma (genus), Branchiostomatidae (family), Amphioxiformes (order), Leptocardii (class), Cephalochordata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0005975 carbohydrate metabolic process; GO:0006006 glucose metabolic process; GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GLVEECCYNVCDYSQLESYCN
  • Length:  21
  • Propeptide:  MNLSSVYVLASLAVVCLLVKETQAEYLCGSTLADVLSFVCGNRGYNSQPRRSVSKRAIDFISEQQAKDYMGAMPHIRRRRGLVEECCYNVCDYSQLESYCNPYSTAPATATPVRTTEPQPEEAEDDPLDGMVGDQAPLGSIENIENLVYHYDSDDITIDAAKMEPKKLKEILGSFEDKKANPVFPFIRQSKNIKPNKFPDSFAHQFPTDLVEEEPTNEIPESPSQKPTLERLGYKHNQTDKKEPTENNNNNNRARDNRTKSSTVEPHTVPDYISKQYTHKPLITLPRGTPRRIESRDSYHLTELR
  • Signal peptide:  MNLSSVYVLASLAVVCLLVKET
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  6-11
  • Structure ID:  AF-P22334-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006133_AF2.pdbhor006133_ESM.pdb

Physical Information

Mass: 279159 Formula: C101H148N24O38S4
Absent amino acids: AFHIKMPRTW Common amino acids: C
pI: 3.33 Basic residues: 0
Polar residues: 12 Hydrophobic residues: 4
Hydrophobicity: -20.95 Boman Index: -3121
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 64.76
Instability Index: 7348.57 Extinction Coefficient cystines: 4720
Absorbance 280nm: 236

Literature

  • PubMed ID:  1701257
  • Title:  Evolution of the insulin superfamily: cloning of a hybrid insulin/insulin-like growth factor cDNA from amphioxus.